Bisquick Impossible Pizza Pie

Featured in: Hearty and Delicious Meals

This Bisquick impossible pizza pie combines seasoned ground beef, pepperoni, onions, and mozzarella for a filling casserole-style dish. A simple batter of Bisquick, eggs, and milk bakes to a light, fluffy crust over layers of savory beef and melty cheese, all brought together with zesty marinara. With minimal prep, this is a convenient and family-friendly weeknight meal that offers classic pizza flavors with hearty comfort. Customize with extra pepperoni on top for more flavor and an irresistible golden finish.

A woman is sitting at a table with a plate of food in front of her. The plate contains a dessert with berries on top.
Updated on Sun, 22 Feb 2026 16:56:49 GMT
A slice of Bisquick Impossible Pizza Pie with pepperoni and cheese. Pin it
A slice of Bisquick Impossible Pizza Pie with pepperoni and cheese. | recipebyme.com

This Bisquick Impossible Pizza Pie was my quick fix for pizza cravings on a busy weeknight when delivery just would not do. The recipe brings together all the best parts of pizza and a classic casserole for a fuss-free family favorite that feels comforting but effortless. If you have a box of Bisquick and some basic ingredients on hand you are halfway to a bubbling golden pie with all the savory flavors you crave.

I first tried this after my kids came home from school asking for pizza and I could not say no. They now call it pizza pie night and it always gets cheers at the table.

Ingredients

  • Ground beef: choose fresh lean ground beef for a hearty base and balanced flavor
  • Chopped pepperoni: adds a classic pizza pop and crisp edges if you tuck some on top
  • Diced onion: give sweetness and depth so do not skip even if you are not an onion lover
  • Salt and black pepper: brings basic seasoning and ties together other flavors
  • Paprika: adds mild smokiness and rich color Spanish or Hungarian work equally well
  • Italian seasoning: a mix of oregano basil and more for traditional pizza vibes
  • Onion powder: a little boost to the onion flavor
  • Crushed red pepper flakes: give just the right heat choose your level based on your spice preference
  • Minced garlic: gives that unmistakable Italian aroma fresh is best but jarred works fine
  • Marinara sauce: acts as the pizza sauce layer so pick a flavorful robust brand or use homemade
  • Bisquick: binds everything and creates the fluffy impossible crust
  • Eggs: hold the batter together and provide a rich tender texture
  • Milk: brings moisture use whole milk for extra creaminess but any dairy milk works
  • Shredded mozzarella cheese: melts beautifully and brings gooey stretches of cheese pick a quality whole milk mozzarella for best results

Instructions

Brown the Meat and Onions:
Start by heating a skillet over medium heat and add the ground beef and diced onion. Cook them together slowly breaking up the beef and stirring often until the meat is fully browned and the onions are soft. This step builds a savory flavor base that will make the whole pie taste rich and hearty.
Add Seasonings and Pepperoni:
Now sprinkle in salt black pepper paprika Italian seasoning onion powder and crushed red pepper flakes. Stir continuously so the spices bloom in the hot fat and coat each piece. Add the chopped pepperoni and cook for a few more minutes to release their oils and deepen the pizza aroma.
Mix in Sauce and Garlic:
Drain away any excess grease if necessary so the pie is never greasy. Add the marinara sauce and minced garlic. Stir everything well until evenly combined then remove the pan from heat to keep the flavors bright and the texture saucy not runny.
Prepare the Bisquick Batter:
In a medium bowl whisk together Bisquick eggs and milk until a smooth batter forms. The mixture should be lump-free and pourable but not too thin. This is the secret to the impossibly light crust.
Assemble the Pie:
Preheat your oven to four hundred degrees Fahrenheit which ensures a crisp golden crust. Spray a deep pie pan well with cooking spray. Spoon half the beef mixture into the dish and sprinkle with one cup of mozzarella. Repeat with the remaining beef and cheese so every layer is packed with flavor.
Add Batter and Toppings:
Slowly pour the Bisquick batter evenly over the surface. Let it seep into all the nooks but do not stir. Top with extra slices of pepperoni for a classic pizza look.
Bake the Pie:
Place the pie in the oven and bake for twenty five minutes. You will know it is ready when the top is golden brown and set and the cheese has melted into bubbling perfection. Let it cool a few minutes before slicing so every piece holds together.
A slice of pizza with pepperoni and cheese on a white plate.
A slice of pizza with pepperoni and cheese on a white plate. | recipebyme.com

I am extra attached to the pepperoni because my dad used to sneak a few crispy edges from the top just as it came out of the oven. Those little bubbles of spicy flavor bring me right back to childhood pizza nights.

Storage Tips

Store leftovers wrapped well in the fridge for up to three days. To reheat use the oven or toaster oven for best texture so the crust stays crisp. Microwave works for speed but the pie will be softer.

Ingredient Substitutions

You can use Italian sausage or ground turkey instead of beef for a different profile. Feel free to substitute a different cheese or use a blend for extra tang. If you want vegetarian just swap the meat for sautéed mushrooms and peppers.

Serving Suggestions

Cut the pie into wedges and serve with a crisp green salad for balance. It also goes great with a side of roasted veggies or a big bowl of minestrone. For parties slice smaller squares for the ultimate finger food.

Cultural and Historical Context

The impossible pies became a hit in American kitchens in the seventies. Boxed baking mixes like Bisquick promised quick family meals and this pie was an easy clever spin on pizza that fed a crowd with little effort. Now it is a nostalgic classic that keeps popping up at potlucks and cozy Sunday suppers.

Seasonal Adaptations

In summer add sliced fresh tomatoes and basil to the base In fall use roasted butternut squash for a touch of sweetness Near the holidays sneak in chopped olives mushrooms or even artichokes for a festive twist

Success Stories

My friend with picky eaters doubled the cheese and no one at her table could tell there were hidden veggies in the mix. Another neighbor told me the pie got her through new baby fatigue since she could whip it up in advance and reheat by the slice all week. People love how kitchen staples create something special with almost no fuss.

Freezer Meal Conversion

Fully bake the pie let it cool and wrap tightly. Freeze up to two months. When ready to eat thaw overnight in the fridge then reheat uncovered in the oven until bubbling and golden. The crust does not get soggy and tastes like fresh baked.

A slice of pepperoni pizza with cheese and tomato sauce on a white plate.
A slice of pepperoni pizza with cheese and tomato sauce on a white plate. | recipebyme.com

Whenever I serve this at family gatherings it disappears faster than any other dish so plan for seconds and happy faces around the table.

Recipe FAQs

→ What can I use instead of ground beef?

Ground turkey, pork, or chicken work well as alternatives to ground beef. You can also opt for plant-based substitutes.

→ Can this be made ahead of time?

Yes, assemble the pie ahead and refrigerate before baking. Bake when ready to enjoy for best texture.

→ How do I prevent a soggy crust?

Drain grease from the beef mixture thoroughly and avoid over-saturating with marinara sauce.

→ What vegetables pair well in this pie?

Bell peppers, mushrooms, or spinach add great flavor and nutrition alongside onions and pepperoni.

→ Can I freeze leftovers?

Yes, cool completely, cut into portions, and freeze in airtight containers. Reheat in the oven until warmed through.

Bisquick Impossible Pizza Pie

Savor ground beef, pepperoni, and mozzarella baked with a light Bisquick batter for a pizza-inspired meal.

Prep Time
15 min
Cook Time
25 min
Total Time
40 min
By: Sana

Category: Main Dishes

Skill Level: Easy

Cuisine: American

Yield: 6 Servings (1 pie)

Dietary Categories: ~

Ingredients

→ Meat and Protein

01 1 pound ground beef
02 1/4 cup chopped pepperoni, plus extra for topping

→ Vegetables

03 1 medium onion, diced

→ Seasoning

04 1/2 teaspoon salt
05 1/2 teaspoon ground black pepper
06 1 teaspoon paprika
07 1 teaspoon Italian seasoning
08 1 teaspoon onion powder
09 1/4 teaspoon crushed red pepper flakes
10 1 tablespoon minced garlic

→ Sauce

11 1 cup marinara sauce

→ Batter

12 1/2 cup Bisquick baking mix
13 2 large eggs
14 3/4 cup whole milk

→ Cheese

15 2 cups shredded mozzarella cheese

Steps

Step 01

In a large skillet over medium heat, cook ground beef with diced onion. Add salt, black pepper, paprika, Italian seasoning, onion powder, and crushed red pepper flakes. Continue cooking until beef is thoroughly browned.

Step 02

Stir in chopped pepperoni and cook for 2 minutes. Drain off excess grease. Add marinara sauce and minced garlic, mixing until combined. Remove skillet from heat.

Step 03

In a mixing bowl, whisk Bisquick, whole milk, and eggs until smooth and free of lumps.

Step 04

Coat a 9-inch pie pan with nonstick cooking spray. Spread half of the beef mixture in the pie pan, top with 1 cup shredded mozzarella cheese. Add remaining beef mixture, sprinkle another cup of mozzarella, then evenly pour Bisquick batter over entire surface. Garnish with reserved pepperoni.

Step 05

Place pan in preheated oven at 400°F. Bake for 25 minutes or until golden brown and set in the center. Rest a few minutes before slicing and serving.

Notes

  1. Let the pie rest 5-10 minutes before cutting for cleaner slices.

Required Equipment

  • Large skillet
  • Mixing bowl
  • 9-inch pie pan
  • Whisk
  • Oven

Allergen Information

Check each ingredient for potential allergens and consult a healthcare professional if needed.
  • Contains wheat, dairy, and eggs.

Nutritional Info (per serving)

This data is provided as a guide and doesn't replace medical advice.
  • Calories: 385
  • Fats: 23 g
  • Carbohydrates: 18 g
  • Proteins: 25 g